节点文献
恒河猴海洛因依赖动物模型的建立
Establishment of animal model of heroin dependent macaca mulatta
【摘要】 目的:用吗啡依赖猴作对比,对海洛因依赖猴模型进行研究。方法:给猴每日3 次臀部皮下注射海洛因,连续注射10 周。结果:随着注射海洛因时间的延长,猴的戒断症状逐渐加重。结论:本实验可使猴在10 周内形成海洛因依赖动物模型,具有成瘾过程平稳、海洛因用量少、成瘾时间缩短等优点。
【Abstract】 OBJECTIVE:To study heroin dependent macaca mulatta model through contrast to morphie dependent Macaca mulatta.METHOD:Macaca mulatta in this study were injected subcutaneously in buttock with heroin three times a day for ten weeks.RESULTS:Withdrawal sympotms deteriorated as injection period of heroin was protracted.CONCLUSION:This study can turn macaca mulatta into heroin dependent animal model.It has the advantages such as stable addiction process,low dose of heroin,shorter period of addiction and etc.
- 【文献出处】 中国现代应用药学 ,CHINESE JOURNAL OF MODERN APPLIED PHARMACY , 编辑部邮箱 ,1999年06期
- 【分类号】R-332
- 【被引频次】11
- 【下载频次】109