【摘要】 目的 :改进药物中间体 2 -( 2 -噻吩 )乙胺的合成方法 ,使之适合工业化生产。方法 :以噻吩为原料 ,经Vilsmeier反应制得噻吩甲醛 ,再将Darzen反应、水解、脱羧、与盐酸羟胺缩合等用一锅煮方法制得噻吩 -2 -乙醛总收率可达70.09%;略高于文献。结论:此方法适合工业化生产。更多还原

【Abstract】 OBJECTIVE:In order to improve the synthetic method of 2-(2-Thienyl)ethylamine,a key component of a myriad of biologically active materials,and suit for industrial process.METHOD:The target compound was synthesized from thiophene via Vilsmeier’s reaction,Darzen’s reaction,hydrolysis,decarboxyl and condensation with hydroxylamine hydrochloride,then reducted by Raney Ni.RESULTS:The overall yield ammounted to 70.09%,which was higher than that of literature.CONCLUSION:The method was more suitable for industrial process.更多还原