【摘要】 通过ＳＤ大鼠连续吸入浓度为３４～５０ｍｇ／ｍ３的烹调油烟染毒，观察不同时相吸入烹调油烟对大鼠体内肺及肝组织Ｓ９组分、血清中ＭＤＡ含量的变化，并观察了血液ＶｉｔＣ含量和血清、肺及肝Ｓ９组分ＳＯＤ酶活性的变化。结果表明：烹调油烟具有产生脂质过氧化的作用，可使肝、肺Ｓ９组分及血清中ＭＤＡ含量增加，使血液中ＶｉｔＣ含量减少，并使血清、肝及肺ＳＯＤ酶活性降低，与阴性对照组比较，差异均有显著性（Ｐ＜０．０５）。烹调油烟组随着染毒时间的延长，其体内ＭＤＡ逐渐增加，而ＳＯＤ逐渐降低更多还原

【Abstract】 In order to observe oxidative lesion in of rats.Spranque dawley (SD) rats were exposed to subacute dose cooking oil fumes (COF).Rats of exposure group and negative control group inhaled COF (34～50mg/m 3×30 min/d×20,40,60d) and hot air(25～28℃×30min/d×20,40,60d)respectively.The concentration of malondiadehyde (MDA) and the activity of superoxide dismutase (SOD) in lung and liver S 9 and in serum were tested by spectrophtometry,VitC in serum was tested,too.The results showed that COF could reduce VitC in serum significantly compared with negative control group( P <0.05),while the MDA in serum and lung liver cytoplasm S 9 increased significantly in rats exposed to COF( P <0.05),and the SOD in serum and lung liver cytoplasm S 9 decreased significantly in rats exposed to COF( P <0.05).The oxidative lesion were enharced by COF.A close time effect relation ship was clearly existed. \ \更多还原