【摘要】 异山梨醇经硝酸酯化、盐析及中和合成了５ 单硝酸异山梨醇酯．酯化反应：异山梨醇、硝酸及硫酸的摩尔比为：１．００∶０．５１∶１．５１，室温，２ｈ； 总收率为３４．９％ ，该工艺非常适合工业化生产．更多还原

【Abstract】 Isosorbide5Mononitrate was synthesized by nitric acid esterification,salting out and neutralization. The mole ratio of isosorbide: nitric acid:sulfuric acid was 1.00∶0.51∶ 1.51.The condition of the synthesis is 2 h at room temprature.The overall yield was 34.9%.This process is very useful for industrial prodution.更多还原