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慢性乙型肝炎出现从HBeAg至抗-HBe自发血清转换之后肝病活动性变化的探讨

Researches on the change in activity of liver disease after spontaneous seroconversion from HBeAg to anti-HBe in chronic hepatitis B

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【作者】 柯伟民黄仰甦邓洪李建国姚集鲁

【Author】 Ke Weimin,Huang Yangsu,Deng Hong,Li Jianguo,Yao Jilu Department of Infectious Diseases,The Third Affiliated Hospital of Sun Yat-sen University of Medical Sciences,Shipai,Guangzhou,510630

【机构】 中山医科大学第三附属医院传染病科!广州510630

【摘要】 目的 为了弄清慢性乙型肝炎出现从HBeAg 至抗- HBe 自发血清转换之后,肝病的活动性是否减轻。方法 在除外重叠甲、丙、丁或戊型肝炎病毒重叠感染引起慢性乙型肝炎肝病急性发作的前提下,分别比较慢性乙型肝炎HBeAg 阳性组和从HBeAg 至抗- HBe 自发血清转换组出现肝病急性发作的严重性指标。结果 肝病急性发作的间隔时间、血清谷丙转氨酶和总胆红素水平、凝血酶原时间和死亡的发生率在慢性乙型肝炎HBeAg 阳性组和从HBeAg 至抗-HBe 自发血清转换组两组之间比较没有统计学差异( P> 0 .50 ~0 .05) 。结论 这些结果提示,慢性乙型肝炎出现从HBeAg 至抗- HBe 自发血清转换之后,肝病的活动性没有降低

【Abstract】 Aim In order to clarify whether the activity of liver disease in chronic hepatitis B declines after spontaneous seroconversion from HBeAg to anti-HBe.Methods Besides the acute attack of liver disease in chronic hepatitis B resulted from superinfections by hepatitis A,C,D or E,the indexes of acute attack of liver disease in chronic hepatitis B were compared between the group which HBeAg was positive and the group of spontaneous seroconversion from HBeAg to anti-HBe.Results There weren’t differences in the interval of acute attack of liver disease,the levels of serum alanine aminotransferase and total bilirubin,prothrombin time and incidence of death between the the group which HBeAg was positive and the group of spontaneous seroconversion from HBeAg to anti-HBe ( P >0.50~0.05). Conclusions These results suggest that the activity of liver disease doesn’t decline after spontaneous seroconversion from HBeAg to anti-HBe in chronic hepatits B.

  • 【文献出处】 胃肠病学和肝病学杂志 ,CHINESE JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY , 编辑部邮箱 ,1999年03期
  • 【分类号】R512.62
  • 【下载频次】60
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