【摘要】 进行了188Re标记单克隆抗体3H11最佳标记条件的研究,包括反应时间、反应浓度等对标记率的影响。在最佳标记条件下,纸色谱法分析其标记率>95%,胶体含量<5%。荷瘤裸鼠体内分布实验结果表明,各脏器TNT随时间延长均逐渐升高;标记物通过肾排泄,代谢较慢;在肿瘤部位具有较强的活性。更多还原

【Abstract】 Various factors influencing the direct labelling of monoclonal antibody (McAb)3H11 with 188 Re are studied. By using the optimized procedure, the labelling yield higher than 95% and the content of colloidal 188 Re is less than 5%. The biodistribution of the 188 Re McAb 3H11 in gastric carcinoma bearing nude mice show that 188 Re is ingested in tumor selectively to some extent. Its clearance from tumor is slower than that from most of the other organs or tissues resulting increased ratios of 188 Re concentration in tumor to non tumor tissue(T/NT) with the lapse of time. It is excreted via kidneys.\;更多还原