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HPLC法测定山茱萸注射液中马钱素和莫诺甙的含量
DETERMINATION OF LOGANIN AND MORRONISIDE IN CORNUS OFFICINALIS INJECTION BY HPLC
【摘要】 山茱萸注射液中有多种有效成分,采用高效液相色谱法对山茱萸注射液中的马钱素（Loganin）和莫诺甙（Morroniside）进行分离定量.色谱柱:Kromasil-100℃18柱.流动相:0.05mol/L磷酸二氢钠缓冲液-乙腈（6.4:1）.马钱素和莫诺甙的平均回收率和相对标准偏差分别为99.79%、1.51（n=6）和99.73%、2.75%（n=6）.结果满意,可作为山茱萸主射液质量控制的标准方法.
【Abstract】 A HPLC method was described for determination of Loganin and Morroniside in Cornus of-ficinalis injection. Chromatographic conditions were: column, Kromasil- 100C1H (4. 6 mm ×150 mm); mobile phase, 0. 05 mol/L NaH2PO4-CH3CN (6. 4:1);flow rate,0. 5 ml/min. The average recoveries and relative standard deviations of Loganin and Morroniside were 99. 79%, 1. 51% and 99. 73%, 2. 75% respectively. The method is simple and accurate.
【基金】 河北医科大学药学院植物化学教研室
- 【文献出处】 天然产物研究与开发 ,Natural Product Research and Development , 编辑部邮箱 ,1999年04期
- 【分类号】O657.7
- 【被引频次】23
- 【下载频次】108