【摘要】 目的观察庆大霉素用药早期对听觉作用的不同机理。方法观察单次肌注庆大霉素（１２５ｍｇ／ｋｇ）前及用药后１５，３０，４５，６０，７５ｍｉｎ时，用短声（ｃｌｉｃｋ）和短音（ｔｏｎｅｐｉｐ）（８，４，２ｋＨｚ）刺激诱发ＣＡＰ，观察Ｎ１、Ｎ２振幅、潜伏期变化。结果短声刺激的ＣＡＰ阈值无明显改变，但Ｎ１波潜伏期随时间增加而逐渐延长；用短音刺激的ＣＡＰＮ１波潜伏期亦逐渐延长，但２ｋＨｚ短音刺激Ｎ１波潜伏期延长较缓慢。短声刺激的Ｎ１振幅随时间增加而呈下降趋势，８ｋＨｚ，４ｋＨｚ短音刺激ＣＡＰＮ１振幅呈一先上升后下降的趋势。短声和短音各频率组的ＣＡＰＮ１－Ｎ２间期随时间而延长。Ｎ２振幅无论是短声刺激还是短音刺激均呈下降趋势。结论早期应用庆大霉素可能有神经传导阻滞作用，其耳毒性作用不仅产生于感觉神经的终末端，也可能来源于中枢，这是可逆的，这种神经毒性作用也有频率特异性。更多还原

【Abstract】 Objective To study the effect of a single dose of Gentamicin on the inner ear. Methods The faceing nerve canal electrod was used to observe the amplitude and latency of N 1、N 2 way of the compoud action potential(CAP) before and after exposure to gentamicin. Results There was a tendency of increase of amplitude of N 1 for a moment, decreasing then after the gentamicin was injected and decreasing continued of N 1. The latency duration was increased gradually both N 1 and N 2. Conclusion The result suggests that a single doses of gentamicin affect the nerve and not the OHC.更多还原