【摘要】 研究植物源性钙通道阻滞剂粉防己碱（Ｔｅｔ）对大鼠膀胱平滑肌的作用。结果发现，在整体实验中，Ｔｅｔ８ｍｇ／ｋｇ灌胃能在较少影响血压、心率的情况下，降低膀胱平滑肌的收缩力（Ｐ＜０．０１）。在离体实验中，Ｔｅｔ（１０、３０μｍｏｌ／Ｌ）能浓度依赖性地非竞争性抑制由ＫＣｌ引起的大鼠正常和肥厚膀胱平滑肌的收缩反应，ＰＤ２′值分别为４．３５和３．７９。在连续每ｄ灌胃Ｔｅｔ８ｍｇ／ｋｇ６周后，能减轻膀胱重量并改善形态学变化，且明显降低膀胱对外源性激动剂如ＫＣｌ的反应性（Ｐ＜０．０１）。提示Ｔｅｔ在治疗某些泌尿系统疾病如膀胱激惹综合征等有一定的应用前景更多还原

【Abstract】 Tetrandrine (Tet) is a calcium channel blocker derived from plant In vivo, the contractile force of bladder smooth muscle was depressed by Tet at a dose of 8 mg/kg (P<001) meanwhile bloodpressure and heart rate were slightly affected In vitro, Tet (10,30 mol/L) could dosedependently and noncompetivively depress the contraction of normal and hypertrophic rat bladder caused by KCl, with the PD2 values being 435 and 379 respectively. At a dose of Tet 8 mg/kg for 6 weeks, Tet could reduce the bladder weight and the responsiveness of bladder to KCl significantly(P<001), and improve morphological changes of hypertrophic rat bladder It is suggested that Tet may be of value in the treatment of some urological system disorders such as irritable bladder syndrome更多还原