【摘要】 采用乳液固化法制备了阿拉伯胶牛血清白蛋白毫微粒， 透射电子显微镜测定微粒的平均粒径为 （２２８±６１）ｎｍ （ｎ＝ ３００）。以５－氟尿嘧啶为模型药物， 将５－氟尿嘧啶阿拉伯胶－白蛋白毫微粒在酸性条件下１００ ℃水解２０ ｈ， 测得５－氟尿嘧啶的平均包封率为３０．１１％ 。体外试验结果表明， ５－氟尿嘧啶毫微粒在３７ ℃０．１ ｍ ｏｌ／Ｌ盐酸液中３６ ｈ 累计释药达８８．２％更多还原

【Abstract】 fluorourail(5-Fu) nanoparticles w ere prepared by em ulsion m ethod, w ith gum acacia and bovine serum e album in being chosen as carriers. The particle size distributon w as m easured under a transm ission eletron m icrocope and the arithm etic m ean diam etrer w as (228±61) nm (n= 300). The m ean encapsulation efficiency of the 5-Fu nanoparticles w as 30.1% w inthin 36 h. Up to 88 % drug release w as observed from gum acacia-album in nanoparticles.更多还原