【摘要】 比较了两种测定动物气道反应性的方法： 整体容积描记法和气道内压法。发现前者能测定多个肺通气功能指标， 与临床可比性强， 结果精确， 其中０．１ ｓ用力呼气量 （ＦＥＶ０．１ ） 能较好地反映组胺刺激后气道收缩反应， 与组胺浓度呈显著负相关， 相关系数ｒ＝ －０．９６１； 后者测定方法简便， 重复性好， 能全程动态观察气道内压 （ＩＰ） 及其下降的最大速率（－ｄＩＰ／ｄｔｍ ａｘ） ，可较好反映组胺刺激后气道收缩反应，与组胺浓度呈显著正相关， ｒ分别为０．９６１ 及０．９７３，－ｄＩＰ／ｄｔｍ ａｘ 还可能是一种新的反映小气道功能的敏感指标。更多还原

【Abstract】 Two methods for determining the airway responsiveness of small animals were established and compared. It was found that BP method could be used to measure several parameters of pulmonary function, one of which, the forced expiratory volume in 0 1 s (FEV 0 1 ) , could precisely reflect the contract intensity of airway after histamine stimulation, and IP method could be used to measure the IP and dIP/dtmax during expiration. The correlation coefficients between the values of FEV 0 1 , IP or dIP/dtmax and the concentration of histamine were -0.961、0.961、 0.973 respectively ( P <0 01). The results suggested that dIP/dtmax might be a sensitive index for small airway resistance.更多还原