【摘要】 目的：探讨雷公藤联合小剂量ＣｓＡ对小肠移植（ＳＢＴ）排斥反应的作用机制。方法：通过对小鼠ＳＢＴ术后不同时相移植小肠的组织病理学改变和脾组织中白细胞介素－４（ＩＬ－４）的基因转录水平的检测，对不同的免疫抑制方案进行评估。结果：雷公藤多甙（ＴⅡ）联合小剂量ＣｓＡ抑制移植术后免疫排斥反应的效果明显优于小剂量ＣｓＡ，与全量ＣｓＡ疗效相同。结论：雷公藤多甙联合小剂量ＣｓＡ可抑制小鼠ＳＢＴ术后的急性排斥反应，其作用机理可能为抑制ＩＬ－４基因转录更多还原

【Abstract】 Objective:To study in the mechanism of T Ⅱ combined with CsA in SBT rejection.Methods:The different immunosuppressive protocals were evaluated by the observation of pathological changes in intestinal grafts post SBT operation in different periods dynamically and the assayment of transcription level of IL 4 coding genes in postoperative spleens.Results:T Ⅱ combined with partial dose CsA had more strong capability in the inhibition to rejection than partial dose CsA alone and was as well as the effection of full dose CsA.Conclusion:T Ⅱ combined with partial dose CsA could inhibit the episode of acute rejection after SBT in mouse.It is the probable mechanism that it could block the IL 4 transcription.更多还原