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肝纤维化指标检测在病毒性肝炎中的应用
Clinical application of hepatic fibrosis index in hepatitis
【摘要】 目的 探讨血清透明质酸( H A) 、Ⅲ型前胶原( PⅢ P) 、Ⅳ型胶原( C I V) 联合检测在病毒性肝炎肝纤维化发生、发展及治疗过程中的临床意义。方法 利用 R I A 法对病毒性肝炎患者(212 例) 、正常对照组(83 例) 进行 H A、 PⅢ P、 C I V 含量测定。两组均数差异显著性分析采用t 检验。结果 肝炎患者3 项指标与正常对照组比较差异有显著意义( P< 0 .01) ,并且浓度随慢性迁延性肝炎( C P H) →慢性活动性肝炎( C A H) →肝硬化( L C) 逐渐升高( P< 0 .05) 。结论 H A、 PⅢ P、 C I V 多指标联合检测对肝病的诊断、病情观察、判定疗效及预后有重要意义;对 C P H 和 C A H 的鉴别诊断具有一定价值。
【Abstract】 Objective To explore the clinical significance during the course of clinical development and treatment in hepatic sclerosis, three items serological index were observed. Methods Contents of serum hyaluronic acid(HA),type Ⅲ procollagen (PⅢP),type IV collagen (CTV) were detected by radioimmunoassay in hepatitis hepatic sclerosis(212 cases) and control group(83 cases). Analysis of difference significance between two groups mean adopted t ?test. Result Compared with control group, contents of 3 items index in hepatic sclerosis have significant difference ( P <0.01).Conclusions Detection of HA PⅢP,CIV,HA have important clinical significance for diagnosis,observation of patients’ condition,determination of curative effect and prognosis in hepatitis.
【Key words】 hepatitis fibrosis hyaluronic acid type Ⅲ procollagen collagen Ⅳ;
- 【文献出处】 铁道医学 ,RAILWAY MEDICAL JOURNAL , 编辑部邮箱 ,1999年03期
- 【分类号】R512.604
- 【下载频次】17