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急性肾小球肾炎患儿血和尿中一氧化氮和环鸟苷酸的变化

THE CHANGES OF URINARY AND PLASMA NO AND cGMP IN CHILDREN WITH ACUTE GLOMERULONEPHRITIS

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【作者】 张敬京杨霁云丁洁俞礼霞

【Author】 Zhang Jinjing,Yang Jiyun,Ding Jie,Yu Lixia Department of Pediatrics,First Affiliated Hospital,Beijing Medical University,Beijing,100034 OBJECTIVE

【机构】 北京医科大学第一医院儿科!北京100034

【摘要】 目的:测定急性肾小球肾炎患儿血和尿中一氧化氮和环鸟苷酸,以期了解一氧化氮在急性肾炎发病过程中的变化。 方法:分别采用分光光度和放射性免疫分析的方法测定了17 例急性肾小球肾炎急性期患儿血和尿中的NO-2 / NO-3 和cGMP,并对6 例患儿进行了急性期和恢复期的动态观察。 结果:17 例急性期患儿血中NO 明显升高(69-2 ±15-7 μm ol/L vs 31-3 ±4-6 μm ol/L,P< 0-05) ,尿中cGMP 降低(366-1 ±39-0p mol/ m g vs637-6 ±78-6 pm ol/ m g ,P< 0-05) ,但尿中NO-2 / NO-3 和血cGMP 与正常对照组差异不显著。动态观察的6 例患儿急性期尿NO 和cGMP 明显低于恢复期(590-8 ±141-4 n mol/ m g vs 1605-6 ±149-2 n m ol/ m g ,P< 0-05) ;(283-4 ±61-7 pm ol/ m g vs 1083-3 ±336-9 p mol/ mg ,P< 0-05) 。同时急性期血中NO 明显高于恢复期(105-9 ±27-3 μmol/ Lvs 46-5 ±10-1 μm ol/L,P< 0-05) 。 结论:急性肾炎患儿在?

【Abstract】 To investigate the changes of urinary and plasma NO and cGMP in children with acute glomerulonephritis(AGN)and its significance in the pathogenesis of AGN. METHODOLOGY Seventeen children with AGN and eighteen healthy children were involved in this study.Urinary and plasma NO 2/NO 3 were determined with biochemical assays.The levels of urinary and plasma cGMP were determined with radioimmunoassay.In six of the seventeen AGN patients,dynamic changes of urinary and plasma NO and cGMP were investigated. RESULTS As compared to the controls,the mean plasma NO 2/NO 3 was found significantly increased (69 2±15 7 μmol/L vs 31 3±4 6 μmol/L, P <0 05)and urinary cGMP decreased (366 1±39 0 pmol/L vs 637 6±78 6 pmol/L, P <0 05)in the 17 AGN children.No significant difference in urinary NO 2/NO 3 and plasma cGMP was found between the AGN patients and the control.In the follow up study of the six AGN patients,urinary NO 2/NO 3 and cGMP were found significantly decreased at the acute phase as compared to those at the recovery phase(590 8±141 4 vs 1605 6±149 2 nmol/mg;283 4±61 7 vs 1083 3±336 9 pmol/mg, P <0 05),while plasma NO 2/NO 3 was significantly increased at the acute phase as compared to those at the recovery phase(105 9±27 3 vs 46 5±10 1 μmol/L, P <0 05). CONCLUSION Remarkable changes of urinary NO 2/NO 3 and cGMP occur in AGN children.NO might play an important role in the pathogenesis of AGN.

  • 【文献出处】 肾脏病与透析肾移植杂志 ,CHINESE JOURNAL OF NEPHROLOGY, DIALYSIS & TRANSPLANTATION , 编辑部邮箱 ,1999年01期
  • 【分类号】R726.9
  • 【下载频次】23
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