【摘要】 目的用烹调油烟对大鼠进行亚急性染毒观察肝组织病理形态改变，并通过测试肝细胞匀浆ＳＯＤ活性及ＭＤＡ含量的变化，探讨烹调油烟是否对肝组织具有损伤作用。方法采用动式吸入烹调油烟浓度为４０ｍｇ／ｍ３为染毒组，吸入加热的空气（２４℃～２８℃）为阴性对照组，每组动物１８只，分三个时相（２０、４０、６０天）观察ＨＥ染色肝组织病理形态改变、检测肝细胞匀浆ＳＯＤ活性和ＭＤＡ含量。结果烹调油烟染毒组肝组织病理形态改变以小灶性坏死为主；烹调油烟可使肝细胞匀浆ＳＯＤ活性明显低于阴性对照组（Ｐ＜００１），ＭＤＡ含量明显高于阴性对照组（Ｐ＜００１）。结论烹调油烟可引起肝组织损伤，同时引起肝细胞匀浆ＳＯＤ活性降低及ＭＤＡ含量增高。更多还原

【Abstract】 Objective To probe the damage of the cooking oil fumes on the liver tissue. Methods The 18 rats of the exposed group were inhaled cooking oil fumes (40mg/m 3,30min/d×20d,40d,60d). The 18 rats of the control group were inhaled the hot air(24℃～28℃). The pathomorphological changes in liver tissue were observed. The activity of superoxide dismutase(SOD) and the content of the malondialdehyde (MDA) in liver cytoplasm were tested. Results The main pathomorphological changes of the liver tissuof the exposed group was local necrosis. The SOD activity of the exposed group decreased and the MDA content in liver cytoplasm of the exposed group increased obviously compared with that of the control group(P<0.01). Conclusion The cooking oil fumes can induce the liver tissue damage,decreass of the SOD activity in liver cytoplasm and increase of the MDA content. [更多还原