【摘要】 目的　探讨单项抗 Ｈ Ｂｃ阳性的健康者接种乙肝疫苗的免疫特点及其应答反应与白细胞介素２（ Ｉ Ｌ２）的关系。方法　对单项抗 Ｈ Ｂｃ 阳性的健康者按是否接种乙肝疫苗分为实验组和对照组１，乙肝五项标记物（ Ｈ Ｂ Ｖ Ｍ）全阴的健康者为对照组２，应用酶联免疫法动态检测其血清 Ｈ Ｂ Ｖ Ｍ 和 Ｉ Ｌ ２。结果　全程免疫后，实验组，对照组１ 和对照组２ 的抗 Ｈ Ｂｓ 阳转率分别为６３％ （６３／１００）、５７％ （２／３５）和７８３％ （４７／６０）。实验组和对照组２ 的抗 Ｈ Ｂｓ 阳转率无论从性别、年龄和抗体滴度比较均有相似的变化规律（ Ｐ＞ ００５）。两组抗 Ｈ Ｂｓ应答者的血清 Ｉ Ｌ ２ 浓度均明显高于各自免疫前的水平（ Ｐ＜ ００１），也明显高于各自同期无应答者（ Ｐ＜ ００５）；而两组无应答者的 Ｉ Ｌ ２ 水平均较各自免疫前升高不明显（ Ｐ＞ ００５）。结论　对单项抗 Ｈ Ｂｃ 阳性的健康者接种乙肝疫苗，可以达到类似 Ｈ Ｂ Ｖ Ｍ 全阴健康者的免疫效果；而不接种疫苗者很少能获得保护性抗体。体内 Ｉ Ｌ ２ 产生不足，可能是乙肝疫苗免疫失败的原因之一。更多还原

【Abstract】 Objective To probe the immuno characteristics of the healthy people with positive anti-HBC inoculated by the hepatitis B vaccine and the relationship between the immuno reaction and IL-2. Methods The experimental group was composed of the healthy people with positive anti-HBc inoculated by hepatitis B vaccine. The control group 1 was composed of the healthy people with positive anti-HBc but without the inoculation of hepatitis B vaccine. The control group 2 was composed of the healthy people with 5 negative hepatitis B markers. The serum HBV-m and IL-2 were dynamically tested using ELISA. Results After three doses of vaccine inoculation, the positive rates of the HBs-Ab of the experimental group, control group 1 and control group 2 were 63%,5.7% and 78.3% respectively. Based on the sex, age and antibody titer, the changing regulation of the experimental group was similar with that of the control group 2 (P>0 05). For these 2 groups, the serum IL-2 of the positive anti-HBs people was significantly higher than that before the immuno inoculation (P<0 01), and that of the people without anti-HBs (P<0 05). There wasn’t significant increase of the IL-2 before and after inoculation for the people without anti-HBs(P>0 05). Conclusion The people with single anti-HBc could produce immunity as enough as the healthy people if they were inoculated by hepatitis B vaccine. In contrast with that, those who had not be inoculated could not been protected from hepatitis. Without enough IL-2 production may be one of the failure reasons of vaccination. [更多还原