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蜕皮甾酮对缺血性脑损伤的影响
Protective Effect of Ecdysterone on Cerebral Ischemia lnduced lmpairment
【摘要】 研究了蜕皮甾酮对抗急性脑缺血作用及对脑缺血再灌注引起的记忆障碍的影响.结果发现:蜕皮甾酮144mg/kg能对抗小鼠急性脑缺血造成的损伤和由于脑缺血引起的体温下降并改善由于脑缺血再灌注引起的学习记忆障碍.蜕皮甾酮10mg/kg还能改善大鼠脑缺血引起的脑水肿并显著降低脑缺血大鼠脑组织钙含量.表明蜕皮甾酮对缺血性脑损伤具有保护作用
【Abstract】 The effects of ecdysterone on cerebral ischemia and amnesia induced by cerebral ischemia damage were studied.The results showed that 14 4 mg/kg of ecdysterone ig protected mice against the acute cerebral ischemia,cerebral ischemia induced hypothermia and cerebral ischemia damage caused amnesia.10 mg/kg of ecdysterone ig also protected rats against cerebral ischemia induced brain edema and decreased calcium content in the cerebral ischemia rat brain.These results indicated that ecdysterone has protective effect on cerebral ischemia induced impairment.
- 【文献出处】 沈阳药科大学学报 ,JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY , 编辑部邮箱 ,1999年02期
- 【分类号】R965.1
- 【被引频次】8
- 【下载频次】88