【摘要】 目的　检测４３ 例鼻咽癌组织中ＥＢ病毒感染和ｐ５３蛋白表达情况，并探讨它们与鼻咽癌发生的关系。方法　ＥＢＥＲ－１ 核酸原位杂交及ＬＭＰ－ １ 和ｐ５３ 免疫组织化学技术。结果　２９ 例ＥＢＥＲ－１ 阳性（６７ ．４％ ） ，２２ 例ＬＭＰ－ １ 阳性（５１％ ），４２ 例ｐ ５３ 蛋白阳性（９７ ％） 。ＥＢＥＲ－ １ 和ＬＭＰ－ １ 阳性率低分化癌（ 分别为７７ ．８ ％ 和５９．３ ％） 高于角化型鳞癌（ 分别为３７ ．５ ％ 和１２ ．５ ％ ，Ｐ＜ ０ ．０５） ，ｐ５３ 蛋白阳性程度在不同组织学类型中也有一定的差别。结论　ＥＢ病毒感染和ｐ５３ 蛋白过度表达与鼻咽癌的发生关系密切更多还原

【Abstract】 Objective To investigate EB virus infection and p53 protein overexpression in 43 cases of nasopharyngeal carcinoma.Methods EBER-1 in situ hybridization and immunohistochemistry with antibody to LMP-1 and p53 protein were applied.Results 29 cases were EBER-1 positive;22 were LMP-1 positive and 42 were p53 protein positive.EBER-1 and LMP-1 were more likely to be positive in poorly differentiated cases than in well differentiated ones.And the degree of p53 protein positivity was also varied in different histological types.Conclusion EB virus infection and p53 protein overexpression are closely associated with the dovelopment of nasopharyngeal carcinoma.更多还原