【摘要】 目的了解抗庚型肝炎病毒抗体（抗－ＨＧＶ）在各型病毒性肝炎患者中的检出情况及临床意义。方法对１９０例不同病原的病毒性肝炎患者进行抗－ＨＧＶ（ＥＬＩＳＡ）检测，对其中抗－ＨＧＶ阳性者进行ＨＧＶ－ＲＮＡ（ＲＴＰＣＲ）检测。结果①在各型病毒性肝炎患者中总的抗－ＨＧＶ阳性率为１２１％（２３／１９０）。②ＨＣＶ感染者中抗－ＨＧＶ的阳性率（２６９％）最高，其后依次为ＨＥＶ（１８２％），ＨＢＶ（１１２％），ＨＤＶ（８３％）。③２３例抗－ＨＧＶ阳性的患者中仅有５例（２１７％）ＨＧＶ－ＲＮＡ同时检测阳性。④抗－ＨＧＶ阳性组与抗－ＨＧＶ阴性组比较，两组肝功能指标无统计学差异（Ｐ＞００５）。结论①抗－ＨＧＶ阳性并不一定代表ＨＧＶ病毒复制或现症感染。②ＨＧＶ致病性可能较弱。③ＨＧＶ可能通过多途径传播。更多还原

【Abstract】 Objective\ To investigate positive rate of anti-HGV in patients with hepatitis A to E.Methods\ Serum anti-HGV was tested in 190 cases of viral hepatitis with different etiology by ELISA based on sythetic peptides,of which serum HGV RNA was also tested in patients who was anti-HGV positive by RT PCR.Results\ ①Anti-HGV was detected in 23 of 190 patients(12.1%),of which only 5 patients(21.7%) were both positive for anti-HGV and HGV RNA.②The positive rate of anti-HGV was 26.9% in patients with hepatitis C,and 18.2% in hepatitis E,and 11.2% in hepatitis B,and 8.3% in hepatitis D.③There was no significant difference in the results of liver functions tests between the groups of anti-HGV positive and negative ( P >0.05).Conclusions\ ①Anti-HGV might represent a marker of exposure to HGV rather than of active HGV infection.②The virulence of HGV might be mild.③Although blood transfusion may be one of the most important routes for HGV transmission,other routes should also be possible.更多还原