【摘要】 目的　了解纤溶活性和血、尿Ｄ－ 二聚体（Ｄ－ ｄ） 水平变化在高血压肾小动脉硬化症（ＨＡＮＳ） 中作用。方法　采用ＥＬＩＳＡ法测定血、尿Ｄ－ ｄ，用发色底物法测定纤溶酶（ｐ∶Ａ）、组织型纤溶酶原激活剂（ｔｐＡ∶Ａ） 及纤溶酶原抑制剂活性（ＰＡＩ∶Ａ） 。结果　原发性高血压（ＰＨ） 组及ＨＮＡＳ组较正常对照组，ｐ∶Ａ 和ｔｐＡ∶Ａ 明显降低，ＰＡＩ∶Ａ和血、尿Ｄ－ｄ 水平显著升高；ＨＮＡＳ组与ＰＨ 组比较，血浆ＰＡＩ∶Ａ 和尿Ｄ－ ｄ 水平差异显著。结论　纤溶活性和血、尿Ｄ－ 二聚体水平变化在高血压肾小动脉硬化的发生发展中具有重要作用更多还原

【Abstract】 Objective To investigate the role of changes of plasma fibrino-lytic activity and D-dimer level with benign arteriolar nephrosclerosis due to primary hyper-tention.Methods To determine p∶A,tpA∶A and PAI∶A using color substrate,and to measure plasma or urine D-dimer using ELISA.Results Both the PH group and the HANS group had signficantly lower p∶A and tpA∶A,and higher level of PAI∶A,plsa-ma & urine D-dimer comparing with normal group;The HANS group had markedly elevated level of plasma PAI∶A and urine D-dimer comparing with the PH group.Conclusion Abnormalities of fibrinolytic activity and D-d level play an improtant role in benign arteriolar nephrosclerosis due to primary hypertention.更多还原