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甲状腺癌bcl-2蛋白及bcl-2 mRNA表达的研究

Expression of bcl 2 Protein and bcl 2 mRNA in Thyroid Carcinoma

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【作者】 曹仁贤文格波刘江华向前

【Author】 Cao Renxian,Wen Gebo,Liu Jianghua,et al(Department of Endocrinology,The First Affiliated Hospital,Hengyang Medical College,Hengyang,421001)

【机构】 衡阳医学院第一附属医院

【摘要】 采用免疫组化和逆转录PCR技术,分别检测甲状腺癌bcl2蛋白及bcl2mRNA表达。结果显示,20例甲状腺癌中bcl2蛋白阳性14例;8例良性甲状腺肿瘤及8例Graves′病均阴性。12例甲状腺癌新鲜手术标本中8例bcl2mRNA表达阳性,而其癌旁组织bcl2mRNA表达阴性。结果表明,bcl2蛋白及bcl2mRNA异常表达与甲状腺细胞凋亡减少有关,在甲状腺癌发生中起一定作用。

【Abstract】 Using immunohistochemical staining method and reverse transcription polymerase chain reaction(RT PCR),we analyzed the expression of bcl 2 protein and bcl 2 mRNA in thyroid carcinomas.The results showed that the expression of bcl 2 protein in 14 thyroid carcinomas were positive,and in 8 benign thyroid tumors and 8 Graves′ disease it was negative.The expression of bcl 2 mRNA was positive in 8 thyroid carcinomas.It suggests that excessive expression of bcl 2 protein and bcl 2 mRNA are involved in apoptosis of thyroid cell and thyroid carcinogenesis.

【关键词】 甲状腺癌bcl-2基因细胞凋亡
【Key words】 Thyroid carcinoma bcl 2 gene Apoptosis
【基金】 国家自然科学基金
  • 【文献出处】 实用癌症杂志 ,THE PRACTICAL JOURNAL OF CANCER , 编辑部邮箱 ,1999年03期
  • 【分类号】R736.1
  • 【被引频次】3
  • 【下载频次】70
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