【摘要】 为了观察在放疗的同期追加化疗能否提高对中晚期食管癌的疗效，将１５６ 例中晚期食管癌随机分成Ａ、Ｂ２ 组，每组７８ 例。Ａ组：每周放疗６ 次，每次２ Ｇｙ；Ｂ组：放疗方式同Ａ 组，另于周末（ 放疗休息日）化疗，ＰＤＤ２０ ｍｇ 、５Ｆｕ ０．５ ｇ／ｍ ２ ，静脉滴注共５ 次。各组照射总肿瘤量为６４ ～７０ Ｇｙ 。随访结果：１、２、３ ａ 生存率，Ａ组分别为６９ ．２ ％（５４／７８） 、２３．１ ％ （１８／７８）和１２ ．８ ％ （１０／７８） ；Ｂ 组分别为７９ ．５％ （６２／７８）、４８ ．７％ （３８／７８）和２０．５ ％（１６／７８）。Ｂ 组２ ａ 生存率明显高于Ａ 组（Ｐ＜ ０．０１），１、３ ａ 生存率２ 组无显著性差异（Ｐ＞ ０．０５）。结果显示，采用每周６ 次、每次２ Ｇｙ 放疗＋ 周末化疗方式治疗中晚期食管癌，近期疗效优于单纯放疗组，无明显毒副作用。更多还原

【Abstract】 patients with advanced esophagel carcinoma were randomized into 2 groups.In group A, the Patients were treated by radiotherapy with 12 Gy/Per week(six fractions);In group B,the patients received radiotherapy(as group A) plus PDD 20 mg and 5 Fu 0.5 g/m 2 once a week for five times.A total tumor dose of 64～70 Gy was used in each group.The results showed that the 1、2、 3 year survival rate in group A was 69.2%(54/78),23.1%(18/78) and 12.8%(10/78) respectively,while in group B it was 79.5%(62/78)、48.7(38/78)、20.5%(16/78) respectively.The 2 year survival rate of group B was significantly higher than that of group A( P <0.01).The authors belive that the combination of chemotherapy with radiotherapy is superior to the simple radiotherapy for treatment of esophageal carcinoma.更多还原