Objective To observe the curative effect of ultraviolet blood irradation and oxygenation (UBIO) on the severe craniocerebral trauma(GCS<8). Methods Patients with severe craniocerebral trauma were randomly divided into 2 groups. Group 1( n =31) was treated with UBIO and group 2( n=27 ) with routine therapy. Results The clinical observation showed that UBIO was superior to routine therapy. Conclusion UBIO no shows any adverse reaction, and it is easy and secure, and is worth implementing.