【摘要】 为探讨P53基因突变与膀胱癌病理分级和临床分期的关系，应用银染PCR-SSCP技术分析46例膀胱癌石蜡标本中P53基因突变情况，结果显示膀胱癌中P53基因突变率为30．4％，分化不良的Ⅲ级膀胱癌P53基因突变率显著高于Ⅰ、Ⅱ级分化较好者。发生浸润和转移的T3－4期膀胱癌P53基因突变率显著高于Tia－T1期表浅性膀胱癌。提示：P53基因突变是膀胱癌恶性程度的生物学标志之一，可用来评估患者的预后。更多还原

【Abstract】 To discuss the genomic status of tumor suppressor gene P53 in bladder cancer, we established the method of PCR-SSCP to analyze P53 gene mutation in 46 bladder cancer tissues. The results revealed the mutation of P53 gene in 14 samples (30. 4% ) of bladder cancer.The rate of mutation in Ⅲ grade bladder cancer was markedly higher than that in Ⅰ, Ⅱ grade. The rate of mutation of P53 gene in bladder cancer in T3-4 phase is significantly higher than that in Tis-T1 phase.It suggested the genic alteration of tumor suppressor gene P53 be an important biological event in bladder cancer prediction.更多还原