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重组人红细胞生成素对慢性肾衰大鼠的疗效
Curative Effect of Recombinant Human Erythropoietin on Hyphemia Caused by Chronic Renal Failure in Rats
【摘要】 建立慢性肾衰贫血大鼠的动物模型后 ,分别用基因重组人红细胞生成素 (r Hu EPO)按 45 0 IU /kg、15 0 IU /kg、 5 0 IU /kg 3组剂量连续 14d皮下注射上述大鼠 ,同时设立阳性对照组及阴性对照组。结果发现r Hu EPO只能治疗肾衰造成的贫血 ,而对肾衰无治疗作用。
【Abstract】 The rats with hyphemia caused by chronic renal failure were divided into 3 groups and subcutaneously injected with recombinant human erythropoietin(rHuEPO) for 14 days at the doses of 450, 150 and 50 IU/kg respectively, using EPOGEN(Amgen,USA) and normal saline as control. The rHuEPO showed curative effect on the hyphemia caused by chronic renal failure. However, it showed no effect on chronic renal failure.
【关键词】 重组人红细胞生成素(rHuEPO);
慢性肾衰;
贫血;
动物模型;
【Key words】 rHuEPO Chronic renal failure Hyphemia Animal model;
【Key words】 rHuEPO Chronic renal failure Hyphemia Animal model;
- 【文献出处】 中国生物制品学杂志 ,CHINESE JOURNAL OF BIOLOGICALS , 编辑部邮箱 ,1999年01期
- 【分类号】R965
- 【下载频次】29