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大鼠体内植入生物材料对CH50及免疫球蛋白的影响

Effects on the Amount of Total Hemolytic Complement Levles(CH 50 ) and Immunoglobulin in Serum Induced by the Implantation of Biomaterials into Rats

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【作者】 朱明华曾怡蒋丽黄聘和吴增树

【Author】 Zhu Minghua Zeng Yi Jiang Li Huang Pinghe Wu Zengshu (Biomedical Material Test Centre of Sichuan, Chengdu 610041)

【机构】 四川省生物医学材料监测中心!成都610041

【摘要】 PES、YP及SR 三种生物材料植入大鼠皮下后7、14、30、60、90 d,采用Beckm an ICS免疫分析系统和标准的总补体量测定方法(CH50法)分析测定血清中免疫球蛋白含量及CH50变化。结果表明YP和SR 材料植入动物IgG、IgA 明显高于对照组,CH50值明显低于对照组动物,PES材料与对照组相比无明显差异。

【Abstract】 Three kinds of biomaterials, PES, YP and SR, were implanted into the subcutaneous tissue of rats and stayed there for 7,14,30,60 and 90 days.Then using the immunity assaying system(Beckman, ICS) and the standard method of measuring the value of total hemolytic complement levels(CH 50 ), we determined the values of immunoglobulin and CH 50 in serum of rats. The results showed the amounts of IgG and IgA of rats with the implanted YP and SR materials were significantly higher than those of the control groups, and their value of CH 50 was significantly lower than that of the control group. There was no significant difference between the PES group and the control group.

【基金】 国家自然科学基金
  • 【文献出处】 生物医学工程学杂志 ,JOURNAL OF BIOMEDICAL ENGINEERING , 编辑部邮箱 ,1999年03期
  • 【被引频次】4
  • 【下载频次】83
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