【摘要】 目的： 制作酒精中毒性股骨头坏死的动物模型。方法： Ｗｉｓｔａｒ 大鼠分为２ 组。实验组以５６ 度白酒灌胃， 剂量１０ｍ Ｌｋｇ·次； 对照组以等量生理盐水灌胃。２４ 周后观测血清学改变及肝脏、股骨头的病理变化。结果： 未见高脂血症， 骨细胞中未见脂滴。股骨头部分骨小梁存在大量空骨陷窝（ ＞ ５０ ％ ） ，骨细胞核固缩， 紧贴骨陷窝壁， 呈“外周化”改变。局部骨髓组织减少。结论： 高浓度白酒灌胃２４ 周， 大鼠股骨头可出现坏死改变。在酒精中毒性股骨头坏死的发病早期， 脂肪代谢紊乱不明显。更多还原

【Abstract】 Objective:To establish animal models for femoral head necrosis induced by alcoholism.Method:The rats(Wistars) were divided into two groups.The rats in experimental group were given by distilled spirit(56%, v/v)(10 mL/kg·time),and isodose NS as controls.The change of serum lipid and the pathological change of the liver and femoral head were determined after 24 weeks.Result:Hyperlipidemia was not observed, without lipid droplets in osteocytes.A lot of empty lacunae were found in the parts of bone trabeculae(>50%),with pyknocyte nuclei and closely contacting to lacunae wall,showing peripherally displaced.Localizable tissue of bone marrow was decreased.Conclusion:Necrosis of femora l head in Wistars was detected after given by distilled spirit for 24 weeks.Lipodystrophy is unclear change in the early pathogenesis of alcoholic necrosis of femoral head.更多还原