【摘要】 用D－10-樟脑磷酸铵作为手性离子对试剂添加到流动相中，在硅胶GF254薄层板上分离了两种芳香醇胺类药物对映体。更多还原

【Abstract】 Two chiral aromatic alcohol amino drugs, Labarol and Bataroc, were resolved by thinlayer chromatography (TLC) on the silica gel GF254 plates (2. 5 cm ×10cm) , by using the ammonium-D-10-camphorsulfonate (CSA) as chiral ion-pair interaction agent which was added to the mobile phase in the ammonium form. All developments were carried out at lower temperature (2-4℃,in a refrigerator) in small glass jars of 250 mL volume. These two drugs were not resolved at room temperature (15-30℃ ). Analytical reagent grade methanol and dichloromethane can be directly used as mobile phase without further drying. The chiral separation occured over a range from 40% to 70% (optimum 67 % ) dichloromethane in the mobile phase volume ratio and 55% to 80% (optimum 60% ) dichloromethane in the mobile phase volume ratio. These separation conditions were easily obtained. This method is relatively inexpensive and attractive.更多还原