【摘要】 孤啡肽是１９９５年底新发现的一种结构与内阿片肽类似的物质，它的发现引发了国际上相关研究的热潮。近年来的研究已经基本阐明了孤啡肽在中枢及外周的分布及其生化与药理特性，并初步发现该物质参与痛觉调制、影响运动与行为、调控递质释放，还可能参与情绪反应与学习记忆、神经内分泌与免疫过程以及胃的活动等，但其确切作用仍有待于进一步阐明。更多还原

【Abstract】 The identification of orphanin FQ(OFQ), a peptide that is similar in structurewith classical endogenous opioid peptide, has resulted in a great upsurge in relative research field.The biochemistry and pharmacology of OFQ has been clarified during recent years. It was foundthat OFQ plays its roles in nociception, locomotion, neurotransmission, neuroendocrine, immuneresponse and the activity of stomach et al.更多还原