【摘要】 雄性ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠，用乌拉坦（１２ｇ／ｋｇ）腹腔麻醉。在侧脑室注射（ｉｃｖ）神经降压素（ＮＴ）（１０，２０μｇ）可引起血压升高或降低，心率减慢。预先ｉｃｖα１受体阻断剂哌唑嗪（１５μｇ／３μｌ），可阻断ＮＴ的中枢升压反应；预先ｉｃｖＭ受体阻断剂硫酸阿托品（２５μｇ／３μｌ），可阻断ＮＴ的中枢降压反应；预先ｉｃｖＨ１受体阻断剂扑尔敏（５０μｇ／３μｌ）或Ｈ２受体阻断剂甲氰咪胍（２５０μｇ／３μｌ），对ＮＴ的中枢心血管效应均无明显影响。实验结果表明：脑中ＮＴ升高可使血压升高或降低；在ＮＴ引起升压反应的中枢环节中，有肾上腺素能α１受体活动的参与；在ＮＴ引起降压反应的中枢环节中，有胆碱能Ｍ受体活动的参与。可以设想，ＮＴ与儿茶酚胺及乙酰胆碱三者一起参与中枢对血压的调节。更多还原

【Abstract】 Injection of neurotensin (NT) (10 and 20 g/rat) into the lateral cerebroventricle (icv) could induce a rise or a drop of blood pressure and a slowing down of heart rate in urethane anaesthetized male rats (12 g/kg). The central pressor and depressor response to NT could be respectively blocked by pretreatment with 1receptor blocker prazosin (15 g/3 l, icv) and M receptor blocker atropine (25 g/3 l, icv). No significant changes in central cardiovascular responses to NT were observed following pretreatment with either H1 receptor blocker chlorpheniramin (50 g/3 l, icv ) or H2 receptor blocker cimetidine (250 g/3 l, icv). In view of the above results it appears that NT, catecholamine and acetylcholine are all involved in central regulation of blood pressure.更多还原