【摘要】 近年来神经组织中缝隙连接（ｇａｐ ｊｕｎｃｔｉｏｎ ， ＧＪ） 的分布和功能研究取得了一些显著进展。分子生物学方法的应用促进了ＧＪ 结构、亚型及生物物理特性的揭示，染料偶联实验和Ｃａ２ ＋ 成像技术为ＧＪ 的功能研究提供了直观有效的手段。ＧＪ 的调控涉及ＧＪ 的表达、导通性的改变等环节。ＧＪ 胞间通讯的基本形式是交换第二信使和电偶联。ＧＪ 在神经胶质细胞和一些脑区神经元的功能实现以及神经微环路的发育形成中起重要作用。更多还原

【Abstract】 In recent years, prominent progresses have been made in the study of the localization and function of gap junctions in the nervous tissue. The application of molecular approaches has advanced the disclosure of the structure, classification and biophysical properties of gap junctions. Dye coupling and Ca 2+ imaging techniques have provided explicit and effective ways for the study of gap junctional functions. The regulation of gap junctions involves the expression of gap junction genes and changes in the conductivity of gap junction channels. Gap junctional intercellular communication includes the exchange of second messengers and electrical coupling between coupled cells. GJ plays an important role in the function of neuroglial cells, neurons in some brain regions and probably in the formation of local neuronal circuits.更多还原