【摘要】 本文综述了阻断NMDA受体离子通道复合物药物对阿片耐受和成瘾发生的影响。行为药理学研究显示 ,非竞争性NMDA受体拮抗剂、竞争性NMDA受体拮抗剂和甘氨酸受点拮抗剂能抑制阿片耐受和戒断反应 ,其药理学特性明显不同于其他类型抗阿片耐受和成瘾的药物 ,阐述了NMDA受体拮抗剂治疗阿片类药物耐受和依赖的生化机制。并指出NMDA受体拮抗剂具有神经毒性。更多还原

【Abstract】 The present review summarizes the effects of drugs that block N methyl D aspartate receptor complex ( NMDA RC) on the development of opiate tolerance and abstinence. Using behavioral pharmacological approaches,pre clinical studies demonstrate that noncompetitive and competitive NMDA receptor antagonists and glycine binding site antagonists can inhibit opioid tolerance and some symptoms of opioid withdrawal. The biochemical mechanisms underlying the inhibition of NMDA receptor antagonists on opioid tolerance and dependence are discussed. There is some extent of neurotoxicity associated with the therapeutic use of NMDA receptor antagonists.更多还原