【摘要】 采用立体定位直流电损毁法，分别损毁双侧下丘、脑桥吻侧网状核、内侧膝状体、黑质，观察核团损毁对大鼠听源性惊厥行为的影响，以寻找与P77PMC大鼠听源性惊厥有关的神经核团。结果表明：双侧下丘损毁后能完全阻断强直阵挛性惊厥，脑桥吻侧网状核损毁能明显减少惊厥发生（P＜0．05），而双侧内侧膝状体及黑质损毁对惊厥无明显影响（P＜0．05）。提示下丘是P77PMC大鼠听源性惊厥的关键核团，而脑桥吻侧网状核可能参与了惊厥回路，内侧膝状体可能并未参与惊厥回路，黑质在此惊厥中的作用尚不明确。更多还原

【Abstract】 To determine the roles of nuclei in seizure pathway, the effect of bilateral nuclei lesions on audiogenic seizures in gened:ally epilepsy-prone rats (P77PMC rats ) was examined. Bilateral inferior colliculus (IC), nucleus reticularis pontis oralis(KPO), medial geniculate nucleus (MG) and substantia nigra (SN) were electrolytically lesioned respectively, and it was foundthat IC lesion completely abolish the seizures, RPO lesion markedly attenuated the frequency and intensity of seizures (P＜0.05), but MG and SN lesion gave no significant effect. Thus, the findings indicated that iC plays a key role in audiogenic seizuresin P77PMC rats, and RPO is also involved in this seizure pathway, but the roles of MG and SN are uncertain.更多还原