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血清、尿中日本血吸虫循环抗原水平动态的实验研究

DYNAMIC CHANGES OF CIRCULATING ANTIGEN OF SCHISTOSOMIASIS JAPONICA IN SERUM AND URINE OF EXPERIMENTAL INFECTED RABBITS

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【作者】 周艺彪阳桂芬杨美霞

【Author】 Zhou Yibiao et al Hunan Institute of Parasitic Diseases, Yueyang 414000

【机构】 湖南省寄生虫病防治研究所

【摘要】 本研究采用McAb-Dot-ELISA的方法,平行地对日本血吸虫病家兔血清和尿液中的日本血吸虫肠相关趋阴极抗原的水平动态进行检测。结果显示,家兔在感染血吸虫第4周后尿液中有28.6%(2/7)可检出CAg,10至12周达到高峰71.4%(5/7);血清中CAg于感染后第2周可检出,8至10周达到高峰,以后缓慢下降。提示家兔在感染10周左右可能是尿液中CAg检出的理想时期。

【Abstract】 McAb Dot ELISA has been used to parallelly detect the dynamic changes of circulatory cathodic antigen(CCA) of schistosomiasis japonica in serum and urine from experimental infected rabbits The results showed that 28 6%(2/7) of the rabbits were CAg positive in the urine 4 weeks after infection,and then reached their peaks 71 4%(5/7) by the 10th to 12th week after infection, while in serum, the CAg became positive by the 2nd week after infection, and the titers reached the peak by the 8th to10th week after infection, and afterwards, the titers slowly declined These hinted that the 10th week or so after infection might be the ideal time to detect the CAg in urine from the infected rabbits

【关键词】 日本血吸虫循环抗原尿液
【Key words】 Schistosomiasis japonicacirculating antigenurine
【基金】 湖南省卫生厅资助
  • 【文献出处】 实用寄生虫病杂志 ,JOURNAL OF PRACTICAL PARASITIC DISEASES , 编辑部邮箱 ,1999年01期
  • 【分类号】R532.210.2
  • 【被引频次】2
  • 【下载频次】22
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