【摘要】 目的了解原发性高血压患者心率变异情况。方法对１０３例原发性高血压患者进行２４小时心率变异性时域分析，并与年龄相当的正常人对照。结果（１）原发性高血压患者时域分析的各项参数均下降（Ｐ＜０．０５）；（２）与无左室肥厚者及正常人比较，伴左室肥厚者每５分钟正常Ｒ－Ｒ间期平均值的标准差（ＳＤＡＮＮ）增高，相邻正常Ｒ－Ｒ间值差值的均方根（ＲＭＳＳＤ）、相邻Ｒ－Ｒ间期差＞５０毫秒的计数占总Ｒ－Ｒ间期数的百分比（ＰＮＮ５０）下降（Ｐ＜０．０５）且昼夜节律明显减弱。结论原发性高血压患者心脏交感、副交感神经活动平衡失调，伴左室肥厚者这种改变更明显。更多还原

【Abstract】 Objective To investigate the heart rate variability in essential hypertensive patients. Methods Heart rate variability was evaluated in 52 essential hypertensive patients with and without left ventricular hypertrophy(LVH) matched in sex and age using 24-hour ambulatory ECG, and compared with age-matched normal controls(n=31). Results (1)All heart rate variability time domain measurements were lower in essential hypertensive patients than those in normal controls (P<0.05).(2)As compared with the normal controls and essential hypertensive patients without LVH, the standard deviation of 5-minute mean R-R interval (SDANN) was increased, the root-mean square of difference of successive R-Rs(RMSSD) and the percentage of difference of successive R-R intervals that exceeded 50 msec (PNN50) were decreased(P<0.05), (3) The circadian rhythm was reduced in the essential hypertensive patients with LVH. Conclusions This investigation suggests that the cardiac sympathovagal balance was blunted in essential hypertensive patients, and such alteration is more significant in the essential hypertensive patients with LVH than those without.更多还原