【摘要】 对安梦（褪黑素）胶囊进行安全性毒理学评价。方法：用每克饲料中含８．３３、１６．６７、３３．３３ｍｇ安梦（褪黑素）胶囊内容物的低、中、高剂量组 ３０ ｄ喂养大鼠。结果：当剂量小于或等于每克饲料含 １６． ６７ ｍｇ安梦（褪黑素）胶囊内容物时，试验组的各项指标未发现异常，当剂量为３３．３３ ｍｇ时所有动物活动明显减少，常处于睡眠状态，摄食明显少于其它各组；体重和血红蛋白、红细胞压积均低于正常对照组。无作用剂量组为中剂量组。最大无作用剂量为 ２． ７６ ｇ／（ｍｍ· ｄ）。结论：一定剂量的安梦（褪黑素）胶囊安全可靠，对人体无副作用。更多还原

【Abstract】 Purpose: The safety and toxicology of the Good-sleep (MLT) capsules were evaluated through 30 day feed test with the substance of Good-sleep (MLT) capsules. Methods: By using 8. 33 mg, 16. 67 mg and 33. 33 mg of substance of Good-sleep capsules/g forage, as a low, medium and high dose respectively, to feed the rats during 30 day. Results: When the dose was at or below 16. 67 mg of substance of the Good-sleep capsules/g forage, each examining quota was found to be in the normal range among the testing groups. In the group the rats were fed with the dose of 33. 33 mg substance of Good-sleep capsules per gram of forage, the animal’s activity was notably decreased, the ingest was significantly less than that in other lower dose groups, and the growth became considerably worse. The weight, HB and HCT were found to be lower than those in the check group. Therefore, the non-effective dose group was the one with the feed of 16. 67 mg of substance of the Good-sleep capsules/g forage. The maximum non-effective dose was found to be 2. 796 g substance of capsules/kg/d. Conclusion: The results obtained imply that the given dose of the Good-sleep (MLT) capsules is safe and reliable, and is free of toxicity and side effects for human body.更多还原