【摘要】 探讨结肠溶口服胸腺肽对氢化泼尼松免疫抑制小鼠的细胞免疫功能的影响。方法：通过制备氢化泼尼松免疫低下的小鼠模型、用细胞毒试验测定小鼠Ｔ细胞亚群水平的变化。结果：其Ｔｈｙ－１和Ｌ３Ｔ４亚群水平明显高于免疫低下对照组（Ｐ＜０．０５或Ｐ＜０．０１）；而与阳性对照组、正常鼠组相比，均无显著性差异，灌胃剂量与Ｔｈｙ－１和Ｌ３Ｔ４亚群水平的相关分析显示量效之间均明显相关（Ｐ＜０．０１）。结论：结肠溶口服胸腺肽和胸腺肽注射剂使用一样，同样具有明显增强和调节细胞免疫功能的作用。口服胸腺肽剂量选用０．３ｍｇ／ｋｇ即能明显提高免疫抑制小鼠的Ｔ细胞亚群水平。更多还原

【Abstract】 Purpose: The aim was to explore the effects of oral thymopeptidin with colonic-coating on immunity of hydroprednison acetate induced immunosuppressed mices. Methods: The immunodeficient BARB/c mices model was prepared by hydroprednison acetate and then the changes of T-cell subsets leveles was detected by cytotoxicity assay. Results: The results showed that Thy-1 and L3T4 subsets leveles in experimental mice were significantly higher than those of control groups (P<O.05 or P<O.01), and did not show significant difference as compared with those of positive and normal control groups. Analysis of the correlation between the dosage and effects iveness showed that Thy-1 and L3T4 subsets leveles were obviously corrleted with the thymopeptidin doses used orally (P <0. 01 ). Condusion: The thymopeptidin oral colonic-coated showed apparently the same effectiveness of enhancing and regulating cellmediated immune function as its injection, and the seleced oral thymopeptidin dose of 0.3mg/kg could obviously rise T-cell subsets leveles in immunosuppressed mices.更多还原