【摘要】 用牛脑微血管平滑肌细胞（ＢＣＭＳＭＣ）体外培养技术，研究白细胞介素１（ＩＬ－１）对ＢＣＭＳＭＣ增殖的影响。浓度为５０ｕ／ｍｌ的 ＩＬ－１与ＢＣＭＳＭＣ共同孵育７２ｈ，即可明显诱导ＢＣＭＳＭＣ增殖。甘糖酯在０．２、０．４、０．８、１．６ｍｇ／ｍｌ的浓度下可显著抑制ＩＬ－１诱导的ＢＣＭＳＭＣ增殖。提示甘糖酯对脑血管疾病的防治作用可能与抑制血管平滑肌细胞的异常增殖有关。更多还原

【Abstract】 The effects of Interleukin-l on the proliferation of bovine cercbromicrovessel smooth muscle cells (BCMSMC) in culture were investigated. IL-1 induced proliferation of cultured BCMSMC was at the concentration of 50u/ml after 72h incubation. The results showed that propylene glycol mannate sulfate (PGMS) antagonized the proliferation of BCMSMC induced by IL-1 at, the concentration of 0.2, 0.4, 0. 8, 1.6mg/ml. It was suggested that the inhibition effects of PGMS on BCMSMC proliferation might probably play an important role in the potential use for cerebrovascular diseases.更多还原