【摘要】 凋亡的调控是细胞生理死亡和肿瘤发生的重要机制．对各种刺激诱导下细胞凋亡机制的分析有助于深入了解肿瘤细胞生物学及发现新的治疗对策．凋亡调控基因ＢＣＬ２家族成员可分为凋亡阻遏基因和凋亡促进基因．这些基因编码的蛋白质分子通过组成和／或影响同二聚体与异二聚体的不同比例而介导其对细胞存活的生物学效应．更多还原

【Abstract】 The regulation of apoptosis is an essential mechanism for physiological cell death and tumorigenesis . The analysis of the genetic machanisms reponsible for susceptibility to or protection from apoptosis stimuli not only enables us to gaininsight into tumor cell biology,but may also prove useful in the development of new therapeutic strategies. Among the proteins coded by the genes of BCL2 family,BCL2,BCL X L,MCL 1,CED 9,BAG 1,E1B 194 and A1 act as death repressors, whereas BAX, BAk, BCL X s and BAD promote cell death. These different functions were shown to be mediated by homodimerzation /heterodimerization of the various family members. Therefore a critical balance between molecules above may determine the fate of cells in reponse to apoptosis inducing conditions.更多还原