【摘要】 ＨＣＶ分离株主要分为４个基因型（ＨＣＶⅠ～Ⅳ），各型间的氨基酸及核苷酸组成同源性均小于８０％，氨基酸变异率分别为Ｃ８％，Ｅ１３５％，Ｅ２／ＮＳ１５３％，ＮＳ３２７％，ＮＳ４３５％，ＮＳ５３９％．不同型别的ＨＣＶ有不同的地区分布特征．根据ＨＣＶ表达产物多肽的保守性、亲水性、抗原性及空间构型等特性，已在ＨＣＶ表达产物中鉴定出一些高度保守的候选Ｂ细胞表位及Ｔ细胞表位，其中Ｂ细胞表位一般为１２～４０肽，Ｔ细胞表位一般为７～９肽，这些Ｂ／Ｔ细胞保守表位的鉴定，将有助于推动ＨＣＶ的免疫治疗及疫苗研究的发展．更多还原

【Abstract】 Hepatitis C virus has four chief genotypes HCVⅠ、Ⅱ、Ⅲ and Ⅳ,whose homology of amino acids and nucliec acids is less than 80% each other.The variation rates of HCV proteins are core 8%,E1 35%,E2/NS1 53%,NS3 27%,NS4 35%,NS5 39%, respectively . According to the characters of conservation, hydrophilicity, antigenicity and conformation,a series of highly conserved T cell and B cell epitopes are identified from the HCV expressed products ,which might be benificial to the prevention and treatment of hepatitis C.In genenal, B epitope is about 12～40 peptides and T epitope 7～9 peptides .更多还原