【摘要】 Ｓｙｎｕｃｌｅｉｎ 是一个广泛分布于中枢神经系统突触前成分内的小分子蛋白质家族， Ｎ 端以１１ 个氨基酸残基为周期的双极性α螺旋是其二级结构的共同特征． Ｓｙｎｕｃｌｅｉｎ 的生理功能目前尚不够明晰， 但大量研究提示ｓｙｎｕｃｌｅｉｎ可能和突触的发育与可塑性有关． 同时， ｓｙｎｕｃｌｅｉｎ 与阿尔茨海默（Ａｌｚｈｅｉｍｅｒ） 病、帕金森（Ｐａｒｋｉｎｓｏｎ） 病等多种神经系统退行性疾病的关系， 及其在乳腺癌侵袭过程中的作用日益受到关注．更多还原

【Abstract】 Synucleins, as a family of small proteins enriched in presynaptic element in CNS, share a secondary structure feature of periodicity of amphipathic α helix with 11 amino acid residues throughout the N terminus. The physiological function of synucleins is unknown, but large quantities of research suggest that synucleins may be implicated in synaptic genesis and plasticity. Also, the relations of synuleins to many neurodegenerative diseases such as Alzheimers and Parkinsons as well as to the invasion of breast cancer have been gaining attention of researchers.更多还原