【摘要】 目的　研究粘附分子 Ｅｃａｄｈｅｒｉｎｃａｔｅｎｉｎ（ Ｅｃａｄｃａｔ）复合体在涎腺腺样囊性癌（ａｄｅｎｏｉｄｃｙｓｔｉｃ ｃａｒｃｉｎｏｍ ａ； Ａ Ｃ Ｃ）中的表达，探讨 Ｅｃａｄｃａｔ 复合体与 Ａ Ｃ Ｃ分化、侵袭和转移之间的关系及其临床意义。方法　采用免疫组化技术检测５０ 例涎腺 Ａ Ｃ Ｃ标本和１０ 例正常涎腺组织中 Ｅｃａｄｈｅｒｉｎ（ Ｅｃａｄ）及其相关蛋白αｃａｔｅｎｉｎ（αｃａｔ）、βｃａｔｅｎｉｎ（βｃａｔ）的表达。结果　５０ 例病例中 Ｅｃａｄ、αｃａｔ 和βｃａｔ共同表达者有２９ 例（５８％ ），但在１８ 例有神经血管侵犯者，其原发灶 Ｅｃａｄｃａｔ复合体成份共同表达仅有７ 例（３９％ ）。结论　正常涎腺上皮组织中 Ｅｃａｄｃａｔ复合体成份呈强烈而稳定的表达，而在涎腺 Ａ Ｃ Ｃ 组织中其表达显著下调； Ｅｃａｄ／ｃａｔ复合体的表达水平与 Ａ Ｃ Ｃ神经血管侵犯呈负相关，但与病理分型无关； Ｅｃａｄ／ｃａｔ复合体的表达下降可能和涎腺组织恶变有关。更多还原

【Abstract】 Objective The aim of this study was to investigate the expression of the E cadherin catenin(E cad cat) complex in human salivary adenoid cystic carcinoma(ACC) and determine the effects of E cad cat expression on tumor differentiation,metastasis and invasion as well as their clinical significance.Methods The expression of adhesion molecules,which included E cadherin,alpha catenin and beta catenin,in 10 cases of normal salivary glands,50 cases of human salivary ACC was investigated by immunohistochemistry.Results Co expression of E cadherin,alpha catenin and beta catenin was detected in 29(58%) of the 50 ACC specimens.Positive staining of E cad cat complex was detected in 7(39%) of the 18 ACC primary sites which had aggressive phenotype of nerve and vasculature.Conclusion Strong positive signals of E cad cat complex were showed in normal salivary glands,and the down regulation expression was observed in ACC cases,The expression of E cad cat complex was associated with a more aggressive phenotype on nerve and vasculature.No association with various histopathologic subtypes was found;Down regulation of E cad cat complex may be associated with canceration of normal salivary glands.更多还原