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得康口服液抗5-Fu致小鼠食量、体重下降及白细胞减少的实验研究

The Experimental Study on the Effects of Dekang Oral Liquid on the Toxicity of 5 Fu

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【作者】 杨广文张素英张晓健马俊英王毓銮

【Author】 Yang Guangwen,Zhang Suying,Zhang Xiaojian et al Shanxi Hospital of Oncoma (Taiyuan 030013)

【机构】 山西省肿瘤医院

【摘要】 目的:观察得康口服液拮抗5-Fu引起小鼠食量、体重下降及WBC减少的作用。方法:将60只雄性昆明种小白鼠随机分为3组,观察组用得康口服液与5-Fu联合灌饲小白鼠,空白对照组单纯灌饲5-Fu,正常对照组灌饲生理盐水,连续给药10天后测定小鼠食量、体重及WBC总数。结果:观察组小鼠日均食量(68.9±12.1)g,体重为(24.1±1.4)g,WBC总数(6.9±2.1)×109/L;与空白对照组比较有显著差异(P<0.01)。结论:得康口服液可以拮抗5-Fu引起的小鼠食量、体重下降及WBC减少的不良反应

【Abstract】 Object:To observe the effects of Dekang Oral Liquid on the toxicity of 5 Fu such as weight lowering and the WBC count lowering of mice.Method:The small mice were infused with Dekang Oral Liquid and 5 Fu,the control group infused only with 5 Fu was also set up.Results:in the former group,the dietary of the mice was (68.9±12.1)g/d,weight (24.1±1.4)g,the average count of the WBC was (6.9±2.1)×10 9/L.The difference between the former group and the control group was significant (P<0.01).Conclusion:Dekang Oral Liquid have effects on the side effects of 5 Fu.

【关键词】 得康口服液5-Fu食量体重白细胞
【Key words】 Dekang Oral Liquid5 FudietaryweightWBC countexperimental study
  • 【文献出处】 山西中医 ,SHANXI JOURNAL OF TRADITIONAL CHINESE MEDICINE , 编辑部邮箱 ,1999年02期
  • 【分类号】R965.1
  • 【下载频次】46
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