【摘要】 目的探讨可溶性白细胞介素－4（solubleinterleukin－4，sIL－4）、细胞间粘附分子－1（in-tercellaradhesionmolecule－1，ICAM－1）在过敏性鼻炎（allergicrhinitis，AR）、咳嗽变异性哮喘（coughvariableasthma，CVA）、哮喘和慢性支气管炎发病中的作用。方法采用酶标法测定12例AR、21例CVA、29例哮喘缓解期、27例哮喘发作期、11例慢性支气管炎患者和10例正常健康人血标本。结果（1）sIL－4：CVA、哮喘发作期和慢支组高于正常组（P＜0．05）。AR、哮喘缓解期与正常组比较无显著性差异。（2）ICAM－1：各组均高于正常组（P＜0．05）。哮喘发作组又高于AR组和哮喘缓解组（P＜0．05）。（3）总IgE：除慢支组外其余各组均高于正常组（P＜0．05）。结论sIL－4、ICAM－1参与气道炎症的形成过程，且其含量的高低与咳嗽的发生呈平行发展关系。更多还原

【Abstract】 Objective To explore the regulatiory mechanism of the soluble interleukin4, intercellar adhesion molecule in patients with allergic rhinitis with cough variable asthma, asthma and chronic bronchitis. Methods Total IgE. sIL - 4. intercellar adhesion molecule - 1 (ICAM - 1) levels in serum were detected in 12 patients with allergic rhinitis(AR), 21 with cough variable asthma(CVA), 29 with remission and 27 with attack stage of asthma, 11 with chronic bronchitis and 10 normal controls by ELISA. ResultssIL-4 concentration in patients with CVA, attack stage of asthma and chronic bronchitis were significantly higher than those of the controls (P＜0.05). Conclusion The sIL- 4. ICAM -1 concentration in patients with cough have a higher levels.更多还原