【摘要】 采用ＬＳＡＢ免疫组化法，对４６例食管癌及３１例贲门癌患者的癌组织进行了ｎｍ２３基因（下简称ｎｍ２３）染色检测。结果显示，食管癌组织染色阳性率明显低于癌旁组织，分化较好的癌组织染色阳性率明显高于分化差的癌组织，原发灶染色阳性率明显高于转移灶，有淋巴结转移的食管癌组织染色阳性率明显低于无转移者。贲门癌中，除有淋巴结转移的贲门癌组织与无淋巴结转移的贲门癌组织染色阳性率差异不显著外，其他相关性同食管癌。两种肿瘤的ｎｍ２３表达情况均与患者的性别、年龄、家族史无明显关系。可见ｎｍ２３在食管癌及贲门癌的发生、发展中所起的作用各有异同更多还原

【Abstract】 The expression of nm23 gene in 46 esophageal carcinomas and 31 cardiac carcinomas was studied by using labelled streptavidin biotin(LSAB) The positive staining rate was lower in esophageal corcinoma tissue than adjacent nontumorous tissue,the rate was lower in poorer differentiated tumorous tissue than better one and the esophageal carcinoma tissue with lymph node metastatsis had lower rate than that of without lymph node metastat sis The relationship was similar with cardiac carcinoma exept that the two rates were close in tumorous tissue with or without metastatsis The results suggest that nm23 gene may play different roles in produce or development of esophageal or cardiac carcinoma更多还原