【摘要】 用不同年龄的Ｗｉｓｔａｒ大鼠为实验动物，用免疫细胞化学改良的ＡＢＣ法及常规组织学方法检测了ＶＰ神经元及相关核团的生后发育。结果表明，生后１天，ＳＯＮ，ＰＶＮ，ＣＮ可辩认；生后５～１０天，ＳＣＮ出现；２０～３０天，室管膜由假复层柱状上皮变为单层柱状上皮，相关核团的细胞变大，胞浆增多，大神经元胞体直径达２０～２５μｍ，与６０～９０天的结构相似。免疫细胞化学（ＩＣＣ）显示，生后１天，ＳＯＮ，ＰＶＮ，ＣＮ可见ＶＰ免疫阳性细胞；５～１０天，此阳性细胞胞浆着色加深。２０～３０天，ＶＰ免疫阳性神经元的大小及着色与生后６０～９０天相似，表明ＶＰ免疫阳性神经元生后即出现，２０～３０天此神经元及相关核团的发育状况已接近成年。更多还原

【Abstract】 Wistar rats were used to study histogenesis of neuronuclei containing VP neurons in hypothalamus during postnatal life by immunocytochemical (ICC) and hematoxylin and eosin (HE) methods. The results showed that on the 1st day after a rats birth(1d) suprapotic nuclei(SON), paraventricular nuclei (PVN) and circular nuclei(CN) of hypothalamus could be identyfied. During 510d, suprachiasmic nuclei(SCN) appeared and the nuclei mentioned above were prominent. During 2030d, the epithelium lining the third ventricle changed from pseudostratified columnar epithelium to simple columnar one, the neurons grew and the cytoplasm of the cells increased and the largest neuron reached 2025m in diameter. The structure of the neurons in hypothalamus between 2030d was similar to that of the ones between 6090d. Immunohistochemically,the VPpositive neurons presented in SON, PVN,CN on 1d and during 5d to 10d the dark blue cytoplasm was observed clearly. The structural characteristics of vasopressin neurons were similar du更多还原