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甲状腺乳头状癌性激素受体的检测

DETECTION OF SEX HORMONE RECEPTOR IN PATILARY THYROID CANCER

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【作者】 刘军王占民张太保

【Author】 Liu Jun, Wang Zhanmin, Zhang Taibao (Dept. of General Surgery, the Affiliated Hospital of Shandong Medical University)$$$$

【机构】 山东医科大学附属医院普外科山东医科大学校医院

【摘要】 对45 份甲状腺乳头状癌患者的石蜡包埋标本用免疫组化方法(ABC法)检测雌、孕激素受体(ER、PgR)。结果表明,性激素受体水平男性患者低于女性;45 岁以下年龄组明显高于45 岁以上年龄组;分化程度越高,性激素受体阳性率越高;未发生淋巴转移组阳性率高于转移组;未发生复发组阳性率高于复发组。提示女性激素是甲状腺乳头状癌致癌因素之一,检测ER、PgR,可作为判断预后的一项参考指标

【Abstract】 An immunohistochemical method utilizing avidin biontin complex(ABC) technique was used in study to detect ER and PgR expressions in 45 samples of patients with papillary thyroid cancer (PTC). The results revealed that the positive staining rate of male was lower than that of female, those aged<45 with PTC was higher than those aged ≥45 with PTC. In the mean time, the positive staining rate was correlated with the cellular differentiated degree, the lympatic metastasis and recurrence. The female hormone as one factors of resulting in PTC, and the detecting of ER and PgR act on a reference role in the prognosis of PTC.

  • 【文献出处】 山东医科大学学报 ,ACTA ACADEMIAE MEDICINAE SHANDONG , 编辑部邮箱 ,1999年04期
  • 【分类号】R736.1
  • 【被引频次】3
  • 【下载频次】38
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