【摘要】 目的：评价P53等多种癌基因与肝细胞肝癌（HCC）分化的关系。方法：对60例HCC标本用免疫组化方法检测P53，P21，C－erbB－2、EGFR基因表达。结果：60例HCC标本中有基因表达41例，其中P53、P21、C－erbB－2、EGFR基因表达。结果：60例HCC标本中有基因表达41例，其中P53，P21，C－erbB－2、EGFR基因表达阳性率分别26.7％、23.3％、31.7％、33．3％。结果显示，肿瘤分化程度与基因表达的阳性率相关，低分化癌阳性率明显高于高分化癌。结论：肝细胞癌基因表达与肿瘤分化有关，提示多种癌基因可能在肝细胞癌发生发展中起重要作用。更多还原

【Abstract】 Purpose: To Study the relationship between expressions of P53, P21, C - erbB - 2, EGFRand differentiation of hepatocellular carcinoma (HCC). Methods: 60 cases of HCCwere investigated by immunohistochemistry using antibodies for P53, P21, C - erbB - 2 and EGFR. Results: 41 cases out 0f 60 cases with HCC showed positive expression of one of more oncogenes, with the opitive rates of 26. 7% in P53,23. 3 % in P21, 31,7 % in C - erbB - 2 and 33. 3 % in EGFR, respectively. It was found that there was a corlelation of degree of tumor differentiation with positive rate of gene expression. The positive rate was much higher in the poorily differentiated than that in the well differcntiated tumor. Condusion:there is a cor- relation of gene expression with tumor differentiation in hepatocellular carcinoma. It suggested that multipleoncogene cvents may play an important rile in carcinogenesis of HCC.更多还原