【摘要】 恶霉灵（ｈｙ ｍｅｘａｚｏｌ） 是一种异恶唑类杀菌剂。它的合成有五种方法。本文用双烯酮与羟胺反应后闭环及乙酰乙酸乙酯与羟胺反应后闭环两条路线合成恶霉灵，总收率分别为８０ ％ 与７５ ％ ，含量＞ ９５ ％更多还原

【Abstract】 Hymexazol which belongs to isoxazoles is a fungicide.Its synthesis have five ways.We prepared it by continuously reacting diketene withNH 2OH follwed acid treatment resulting CH 3COCH 2CONHOH,the whole yield 80%,and treating acetyl acetic ether by the same way ,the whole yield 75%.Their content>95%.更多还原