【摘要】 目的　探讨老年Ｇｒａｖｅｓ 病骨病的发病机制，对不同治疗阶段患者血清骨钙素（ＢＧＰ）及甲状腺功能进行检测并作对比分析。方法　采用放射免疫技术检测Ｇｒａｖｅｓ 病患者血清ＢＧＰ及甲状腺功能指标（ＦＴ３ 、ＦＴ４ 、ＴＳＨ、ＴＧ－ Ａｂ、ＴＭ－ Ａｂ）。结果　Ｇｒａｖｅｓ 病患者血清ＢＧＰ明显升高，相关分析揭示ＢＧＰ与ＦＴ３ 、ＦＴ４ 呈正相关（ＦＴ３ ：ｒ＝ ０．５８２ ，Ｐ ＜ ０．０１；ＦＴ４ ：ｒ＝ ０ ．６２１，Ｐ＜ ０．０１），与ＴＳＨ、ＴＧ－ Ａｂ、ＴＭ－ Ａｂ 无相关（ Ｐ ＞ ０．０５） 。结论　ＢＧＰ 是Ｇｒａｖｅｓ 骨病病情控制与否的一项较敏感性指标，Ｇｒａｖｅｓ 病骨转换受ＦＴ３ 、ＦＴ４ 影响，而与机体免疫状态无相关。提示老年Ｇｒａｖｅｓ 病的防治主要是以抗甲亢治疗为基础Ｔ３ 、Ｔ４ 恢复至正常水平后才能使骨转换率尽快得到控制。更多还原

【Abstract】 Objectives In order to study cause pathogenisis of bone disease in elderly Graves disease.Methods Radioimmunoassary was used to determine serum osteocalin(BGIP) and free FT 3、free thyroxine(T 4)、TSH、TG-Ab、TM-Ab for 48 elderly Graves disease patients(≥60y).Results The results showed that the serum BGP in Graves disease patient was obvious elevated.Correlative analysis suggest the serum BGP corrlated positively with FT 3、FT 4(FT 3:r=0.582,P<0.01;FT 4:r=0.621,P<0.01),but not correlated with TSH、TG-Ab and TM-Ab.Conclusions It is therefore inferred that the serum BGP is a sensitively target for good control in Graves disease .The bone translstion in Graves diseas was affected by FT 3、FT 4 and independent of TSH、TG-Ab and TM-Ab.更多还原